Sinner is the World No. 1 and a -330 favorite to beat the rising American, but there are more concerns about the Italian coming into this match than Shelton. The most notable is that Sinner injured his elbow in his match against Grigor Dimitrov on Monday, and it was uncertain whether or not he would even be able to play on Wednesday.

The 2025 Wimbledon marks Sinner's fourth consecutive year at the tournament. He's currently the No. 1 men's singles player worldwide. He defeated Grigor Dimitrov on Monday, after Dimitrov was injured and retired from the match. Sinner also faced an elbow injury, so Wednesday's match will be the first time he's played since his MRI.

Top-ranked Jannik Sinner has canceled his practice session at Wimbledon after sustaining a right elbow injury the night before in a fourth-round match against Grigor Dimitrov.